Cardioprotective Potential of an SGLT2 Inhibitor Against Doxorubicin-Induced Heart Failure

Erythropoietin protects against doxorubicin-induced heart failure.

The hormone erythropoietin (EPO) has been demonstrated to have cardioprotective properties. The present study investigates the role of EPO to prevent heart failure following cancer treatment with doxorubicin [adriamycin (AD)]. Male Wistar rats (150 ± 10 g) were treated with saline (vehicle control group); with EPO, subcutaneously at 1,000 IU/kg body wt, three times per week for 4 wk (EPO group)...

Cardioprotective effect of Crataegus aronia syn. Azarolus (L) Aqueous Extract Against Doxorubicin-Induced Cardiotoxicity and Heart Failure in Wistar Rats

We examined whether Crataegus aronia (C. aronia) can ameliorate Doxirubicin (DOX) induced cardiotoxicity in rats. Six groups of Wistar rats were divided as: Group I: a control group (administered saline); Group II: administered aqueous extract of C. aronia alone; Group III: administered DOX alone; Group IV: administered concomitant doses of both DOX and C. aronia; Group V: administered DOX firs...

Cardioprotective Effect of Naringin against Doxorubicin Induced Cardiomyopathy in Rats

Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin

Oxidative stress is one of the major factors in doxorubicin (DOX)-induced cardiomyopathy. Lectin-like oxidized low-density lipoprotein (oxLDL) receptor-1 (LOX-1) plays an important role to regulate cardiac remodeling and oxidative stress after ischemia-reperfusion. Therefore, we examined whether or not LOX-1 contributes to the pathogenesis of DOX-induced cardiomyopathy. Cardiomyopathy was induc...

Evaluation of the potential cardioprotective activity of some Saudi plants against doxorubicin toxicity.

Doxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent in the treatment of several tumours. However, its cardiac toxicity limits its use at maximum therapeutic doses. Most studies implicated increased oxidative stress as the major determinant of DOX cardiotoxicity. The local Saudi flora is very rich in a variety of plants of quite known folkloric or traditional...